Sedating tca

In depressed individuals, amitriptyline exerts a positive effect on mood.

TCAs are potent inhibitors of serotonin and norepinephrine reuptake.

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Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). They contain a tricyclic ring system with an alkyl amine substituent on the central ring.

In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation.

Tertiary amine TCAs, such as amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline.

TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use.

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Untoward side effects may be reduced by taking trazodone after meals, and by using bedtime dosing.

They are among the safest pills in medicine -- safer than, for example, Tylenol or penicillin. Tricyclics can make certain illnesses worse: narrow-angle glaucoma, prostatic hypertrophy, and preexisting cardiac arrhythmias.

They won't damage your kidneys, liver, heart, or nervous system. A few patients stop taking tricyclic antidepressants because the side effects are too annoying: dry mouth, constipation, sweating, or grogginess.

Nortriptyline is an option for some animals that experience too much sedation with the parent compound.

Cats: Amitriptyline is commonly used for cats that spray or exhibit inappropriate elimination behaviors.

Tricyclic antidepressants usually don't interact with other medications, but there are exceptions you should know about: This medication must be taken regularly, not just when you feel like you need it.

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